Breast cancer under 40 years of age: increasing number and worse prognosis. 2011

Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
Department of Oncotherapy, University of Szeged, Korányi fasor 12, 6720 Szeged, Hungary. dobiagnes@gmail.com

Breast cancer at a relatively young age with a poor prognosis is currently exhibiting an increasing incidence. In a retrospective cohort analysis of early breast cancer cases after surgery from our institutional patient registry, 141 patients aged ≤ 40 years constituted the younger group, with 300 randomly selected patients aged >40 years as controls. A significant and steady increase was found in the relative number of younger cases during the years 2004-2009. The histological type and grade and the lymph node status of the cancers differed significantly between the two groups, with more aggressive biological behaviour, a more advanced stage and a worse prognosis in the younger group. Half of the cancers in the younger cohort were ER-negative, while two-thirds in the control group were ER-positive. Comparatively more tumours were PR-positive and HER2-negative in the control group than in the younger group. The rates of triple-negative cases were 25% and 13% in the younger age and the control group, respectively (p = 0.026). Significantly higher mastectomy and axillary block dissection rates were observed in the younger age group, and more chemotherapy was administered than in the control group. Our findings demonstrate the significance of breast cancer in cases aged <40 years, and draw attention to the need for appropriate care in these cases.

UI MeSH Term Description Entries
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D015331 Cohort Studies Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. Birth Cohort Studies,Birth Cohort Study,Closed Cohort Studies,Cohort Analysis,Concurrent Studies,Historical Cohort Studies,Incidence Studies,Analysis, Cohort,Cohort Studies, Closed,Cohort Studies, Historical,Studies, Closed Cohort,Studies, Concurrent,Studies, Historical Cohort,Analyses, Cohort,Closed Cohort Study,Cohort Analyses,Cohort Studies, Birth,Cohort Study,Cohort Study, Birth,Cohort Study, Closed,Cohort Study, Historical,Concurrent Study,Historical Cohort Study,Incidence Study,Studies, Birth Cohort,Studies, Cohort,Studies, Incidence,Study, Birth Cohort,Study, Closed Cohort,Study, Cohort,Study, Concurrent,Study, Historical Cohort,Study, Incidence
D017668 Age of Onset The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual. Age-at-Onset,Age at Onset,Onset Age

Related Publications

Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
January 2011, Journal of B.U.ON. : official journal of the Balkan Union of Oncology,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
November 2016, Revista da Associacao Medica Brasileira (1992),
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
June 2009, Seminars in oncology,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
June 2021, JCO oncology practice,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
January 2013, Cancer management and research,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
May 2011, Annals of plastic surgery,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
July 1986, Revista espanola de las enfermedades del aparato digestivo,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
January 1989, Sovetskaia meditsina,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
May 1986, Diseases of the colon and rectum,
Ágnes Dobi, and Gyöngyi Kelemen, and László Kaizer, and Roland Weiczner, and László Thurzó, and Zsuzsanna Kahán
September 1983, Journal of surgical oncology,
Copied contents to your clipboard!