-transparent.png){kind=logo}
A placenta protein, originally termed PP4, was found to inhibit the aPTT in a concentration-dependent manner. PP4 which turned out to be identical with a vascular anticoagulant of the annexin type, inhibits the blood clotting process by binding of the essential lipids in a reaction which is dependent on calcium ions. Also in the presence of calcium PP4 combines with platelet membranes neutralizing their procoagulant effect. By fluorescence-microscopy binding of PP4 to stimulated macrophages is shown. The antithrombotic effect of PP4 is demonstrated by means of thrombelastography of human blood. Coagulation triggered by the addition of thromboplastin/lipid-mixtures is extinguished by PP4.
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
January 1991,
Thrombosis research,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
October 1991,
Chemical & pharmaceutical bulletin,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
February 2006,
Blood,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
August 1995,
American journal of hematology,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
September 1992,
The Journal of biological chemistry,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
January 1991,
Cytogenetics and cell genetics,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
January 1990,
Journal of biochemistry,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
December 2006,
Ceska gynekologie,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
January 2008,
Preparative biochemistry & biotechnology,
J Römisch, and
U Schorlemmer, and
K Fickenscher, and
E P Pâques, and
N Heimburger
August 2003,
Preparative biochemistry & biotechnology,
