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The effect of calcitonin gene-related peptide (CGRP) on parasympathetic contraction of rabbit airway smooth muscle was studied under isometric conditions in vitro. CGRP (10(-7) M) did not contract tracheal smooth muscle, but it potentiated the contractile response to electrical field stimulation (EFS) in a dose-dependent manner, the maximal increase from the baseline response being 14.4 +/- 6.2%. In contrast, the contractile responses to exogenously administered acetylcholine were not altered by this peptide. The CGRP-induced potentiation of the contractile responses to EFS was further augmented by physostigmine (123.1%), but not influenced by phentolamine, propranolol, indomethacin, or thiorphan, an enkephalinase inhibitor. These results suggest that CGRP augments the neurally mediated contraction of rabbit airway smooth muscle probably through a prejunctional mechanism and that this effect may not be modulated by tissue enkephalinase.
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
December 1996,
British journal of pharmacology,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
July 1989,
European journal of pharmacology,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
August 1997,
Gastroenterology,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
February 1988,
Gastroenterology,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
January 2001,
Journal of applied physiology (Bethesda, Md. : 1985),
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
March 1992,
American journal of respiratory cell and molecular biology,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
February 1994,
The Journal of physiology,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
June 1992,
Annals of the New York Academy of Sciences,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
September 1985,
Neuroscience letters,
T Kanemura, and
J Tamaoki, and
S Horii, and
N Sakai, and
K Kobayashi, and
K Isono, and
S Takeuchi, and
T Takizawa
January 1996,
Current eye research,
