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Myocardial cells in monolayer culture were examined ultrastructurally at various times (5 min-24 hr) after addition of ethanol (12.5-500 mM). At 5 min, all concentrations of ethanol induced mitochondrial fusion and a remarkable increase in glycogen granules, and the mitochondrial outer membrane seemed more fragile. These initial ultrastructural changes then recovered with time. Glycogen granules were decreased, then returned to normal more rapidly as the ethanol concentration was increased. Mitochondrial fusion and fragile appearance of the outer membrane were hardly seen at 1 hr in the presence of 12.5 or 50 mM ethanol, but were still evident with higher ethanol concentrations (200 and 500 mM), though less frequently than at 5 and 30 min. Furthermore, 'giant mitochondria' (with at least a five-fold increase in sectional area) appeared in the presence of 200 and 500 mM ethanol with increasing time of exposure. These results are discussed in relation to the direct effects of ethanol.
K Mikami, and
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T Watanabe
April 2003,
Virchows Archiv : an international journal of pathology,
K Mikami, and
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K Mikami, and
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April 1979,
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K Mikami, and
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December 1981,
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K Mikami, and
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August 1986,
Investigative radiology,
K Mikami, and
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T Watanabe
January 1976,
Tumori,
K Mikami, and
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T Watanabe
October 1995,
Molecular and chemical neuropathology,
K Mikami, and
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T Watanabe
February 2000,
Alcoholism, clinical and experimental research,
K Mikami, and
S Sato, and
T Watanabe
August 1987,
Experimental cell research,
K Mikami, and
S Sato, and
T Watanabe
January 1981,
Investigative radiology,
