The variant associations of aortic isthmic coarctation. 2010

Joseph K Perloff
Ahmanson/UCLA Adult Congenital Heart Disease Center, Los Angeles, California, USA. josephperloff@earthlink.net

The term "coarctation" necessarily calls attention to a specific morphologic abnormality of the aortic isthmus. However, in this report, the author seeks to dispel the simplistic notion that coarctation is best characterized by isthmic obstruction, which is only 1 of an assemblage of abnormalities that include the proximal paracoarctation aorta, the distal paracoarctation aorta, the ascending aorta, the transverse aorta, the coronary arteries, the conduit arteries (radial, brachial, and carotid), the retinal vascular bed, dissecting aneurysms, cerebral aneurysms, vascular rings, systemic hypertension, and a decrease in left ventricular interpapillary muscle distance. Some of these abnormalities are secondary to the coarctation, such as collateral arteries and dissecting aneurysms. Others frequently or invariably coexist but are not secondary, such as bicuspid aortic valve and aneurysm of the circle of Willis. Still other abnormalities are seemingly contradictory, such as aneurysmal dilatation of the low-pressure distal paracoarctation aorta, while the high-pressure proximal segment does not dilate significantly. In conclusion, coarctation should be regarded as an assemblage of cardiovascular abnormalities rather than as isolated obstruction of the aortic isthmus.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001017 Aortic Coarctation A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion. Coarctation of Aorta,Coarctation of Aorta Dominant,Coarctation of the Aorta,Aorta Coarctation,Aorta Coarctations,Aorta Dominant Coarctation,Aorta Dominant Coarctations,Aortic Coarctations,Coarctation, Aortic,Coarctations, Aortic

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