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Diltiazem is one of the effective calcium channel blocking agents. Up to now it has not been reported in our country that whether the combined use of digoxin and diltiazem can increase the serum concentration of digoxin The results of a study of ten cases with chronic congestive heart failure showed that diltiazem can increase the serum concentration of digoxin from 38.7% to 49.6%. Four of the ten cases appeared to have signs of digitalis poisoning in the electrocardiogram.
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