Biomaterial Database

Anti-arabinogalactan IgM/IgG ratio: a screening index for leprosy patients. 1990

A Roy, and A Agarwal, and R Ralhan

Malaria Research Centre, Delhi.

The serological activities of arabinogalactan from M. smegmatis and phenolic glycolipid-1 from M. leprae were examined by Enzyme Linked Immunosorbent Assay using sera from 88 patients with leprosy (44 treated and 44 untreated) and 45 normal healthy individuals. Both IgM and IgG type of antibodies were measured against these antigens. The results confirmed the previous observation that anti phenolic-glycolipid-1 IgM antibodies are higher in lepromatous leprosy cases than in normal individuals. However, with arabinogalactan, the ratio of IgM/IgG was more than one in normal individuals and less than one in untreated LL patients. Treated patients fell in both categories. Moreover, a reverse relationship was found between anti PGL-1 IgM titers and anti arabinogalactan IgM/IgG ratio.

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075	Immunoglobulin M	A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin.	Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D008297	Male		Males
D008403	Mass Screening	Organized periodic procedures performed on large groups of people for the purpose of detecting disease.	Screening,Mass Screenings,Screening, Mass,Screenings,Screenings, Mass
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009166	Mycobacterium leprae	A species of gram-positive, aerobic bacteria that causes LEPROSY in man. Its organisms are generally arranged in clumps, rounded masses, or in groups of bacilli side by side.
D004797	Enzyme-Linked Immunosorbent Assay	An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.	ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D005260	Female		Females
D005685	Galactans	Polysaccharides composed of repeating galactose units. They can consist of branched or unbranched chains in any linkages.	Galactan,Polygalactose,Polygalactoses
D006017	Glycolipids	Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)	Glycolipid