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Plasma concentrations and excretion of mecillinam after oral administration of pivmecillinam in elderly patients. 1978

A P Ball, and A K Viswan, and M Mitchard, and R Wise

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D010397 Penicillanic Acid A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed) Acid, Penicillanic
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000560 Amdinocillin An amidinopenicillanic acid derivative with broad spectrum antibacterial action. Mecillinam,FL-1060,Penicillin Hx,FL 1060,FL1060
D000561 Amdinocillin Pivoxil Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. Pivmecillinam,FL-1039,Mecillinam Pivaloyl Ester,Pivamdinocillin,Pivmecillinam Hydrochloride,Selexid,FL 1039,FL1039,Hydrochloride, Pivmecillinam,Pivaloyl Ester, Mecillinam,Pivoxil, Amdinocillin
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

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