BIOMAT Database Logo BIOMAT Database Logo

Immunologic and immunogenetic studies in rheumatic fever and rheumatic heart disease. 1990

K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Department of Cardiology, Medicine and Anatomy, All India Institute of Medical Sciences, New Delhi.

In order to evaluate all the important limbs of the immune system in the same patient population with rheumatic fever (RF) and rheumatic heart disease (RHD) cellular and humoral immune parameters as well as the immunogenetic profile in 265 North Indian patients with RHD were evaluated. They were studied for class in HLA antigens and 165 of them were also evaluated for the class II (DR locus) antigen profile. Data obtained was compared with 400 and 134 healthy controls respectively of the same ethnicity. Humoral immune parameters (Serum immunoglobulins IgG, IgA; Serum complement fractions C3, C4, C3d; circulating immune complexes and B lymphocyte numbers) and cellular immune parameters (total leucocyte and lymphocyte counts; T lymphocyte sub-populations--CD4, CD8 counts; lymphocyte migration inhibition to an extracellular streptococcal antigen, streptolysin 'O') were studied in 23 patients with RF, 21 patients with "inactive" RHD and 20 normal controls. Patients of RHD were noted to have an increased frequency of DR3 (P less than 0.001; Relative risk = 2.3) and a decreased frequency of DR2 (P less than 0.001; Relative risk = 0.3) as compared to the controls. Patients of RF had evidence of an altered regulatory T cell function (increased CD4/CD8 ratio) and decreased cell mediated immunity to streptolysin 'O'. An increased humoral immune response (increased B cell counts, elevated serum IgG, circulating immune complexes and C3d) was noted in patients of RF as well as "inactive" RHD. An integrated pathogenetic model with immune response associated antigens of the DR locus influencing selection of cardiac cross-reactive antigens by the antigen processing macrophages, an altered regulatory T cell function with decreased suppressor T cell activity leading to an abnormal immune response is proposed to explain the pathogenesis of RF.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007111 Immunity, Cellular Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role. Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D007194 India A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi. Republic of India
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012213 Rheumatic Fever A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin. Acute Rheumatic Fever,Arthritis, Rheumatic, Acute,Rheumatism, Articular, Acute,Arthritis, Acute Rheumatic,Inflammatory Rheumatism,Polyarthritis Rheumatica,Rheumatic Arthritis,Rheumatism, Acute Articular,Acute Articular Rheumatism,Acute Articular Rheumatisms,Acute Rheumatic Arthritides,Acute Rheumatic Arthritis,Acute Rheumatic Fevers,Arthritis, Rheumatic,Articular Rheumatism, Acute,Fever, Acute Rheumatic,Fever, Rheumatic,Fevers, Acute Rheumatic,Inflammatory Rheumatisms,Polyarthritis Rheumaticas,Rheumatic Arthritides,Rheumatic Arthritis, Acute,Rheumatic Fever, Acute,Rheumatic Fevers,Rheumatism, Inflammatory
D012214 Rheumatic Heart Disease Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM. Bouillaud Disease,Bouillaud's Disease,Bouillauds Disease,Disease, Bouillaud,Disease, Bouillaud's,Disease, Rheumatic Heart,Diseases, Rheumatic Heart,Heart Disease, Rheumatic,Heart Diseases, Rheumatic,Rheumatic Heart Diseases

Related Publications

K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
[Rheumatic fever--an immunogenetic disease].
July 1992, Harefuah,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Immunologic and clinical correlations in rheumatic fever and rheumatic heart disease.
April 1997, The Pediatric infectious disease journal,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
[Acute rheumatic fever and rheumatic heart disease: immunological studies].
January 1996, Vestnik Rossiiskoi akademii meditsinskikh nauk,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
S., M.S. Immunologic studies in rheumatic fever.
August 1949, Annals of internal medicine,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Immunological studies on acute rheumatic fever and rheumatic heart disease.
March 1984, Journal of clinical & laboratory immunology,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Blood groups, salivary secretion and other immunologic variables in rheumatic fever and rheumatic heart disease.
January 1984, Acta anthropogenetica,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Immunologic studies in rheumatic fever; antistreptolysin patterns in rheumatic children.
August 1946, Journal of immunology (Baltimore, Md. : 1950),
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Immunologic phenomena in the heart in rheumatic fever.
January 1974, Materia medica Polona. Polish journal of medicine and pharmacy,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Rheumatic fever and heart disease follow-up studies.
January 1945, Archivos del Instituto de Cardiologia de Mexico,
K S Reddy, and J Narula, and R Bhatia, and K Shailendri, and M Koicha, and V Taneja, and B Jhingan, and R B Pothineni, and A N Malaviya, and N K Mehra
Rheumatic Fever and Rheumatic Heart Disease.
May 2023, Irish medical journal,
Copied contents to your clipboard!