Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells. 2011

YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
Section of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA 02118, USA.

There is a need for developing vaccines that elicit mucosal immunity. Although oral or nasal vaccination methods would be ideal, current strategies have yielded mixed success. Toll-like receptor 2 (TLR2) ligands are effective adjuvants and are currently used in the Haemophilus influenzae type B vaccine. Induction of humoral immunity in the mucosa is critical for effective vaccination; thus, we sought to determine the effects of TLR2 ligands on human mucosal B cell differentiation. We demonstrate that TLR2 ligands induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28 suggesting that TLR2 induces B cell homing to the gastrointestinal tract. TLR2 stimulation of B cells also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells. These observations suggest that vaccines containing TLR2-ligands as adjuvants could induce mucosal B cell immunity even when delivered in a non-mucosal manner.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D007082 Ileum The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D007144 Immunoglobulin J-Chains A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains. Ig J Chains,J-Chains, Immunoglobulin,Ig J-Peptide,Immunoglobulin J Polypeptide,Immunoglobulin J-Peptide,Chains, Ig J,Ig J Peptide,Immunoglobulin J Chains,Immunoglobulin J Peptide,J Chains, Ig,J Chains, Immunoglobulin,J Polypeptide, Immunoglobulin,J-Peptide, Ig,J-Peptide, Immunoglobulin,Polypeptide, Immunoglobulin J
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008070 Lipopolysaccharides Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed) Lipopolysaccharide,Lipoglycans
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002633 Chemotaxis The movement of cells or organisms toward or away from a substance in response to its concentration gradient. Haptotaxis
D003424 Crohn Disease A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients. Colitis, Granulomatous,Enteritis, Granulomatous,Enteritis, Regional,Ileitis, Regional,Ileitis, Terminal,Ileocolitis,Crohn's Disease,Crohn's Enteritis,Inflammatory Bowel Disease 1,Regional Enteritis,Crohns Disease,Granulomatous Colitis,Granulomatous Enteritis,Regional Ileitides,Regional Ileitis,Terminal Ileitis

Related Publications

YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
April 2011, Immunobiology,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
July 2004, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
January 2011, Clinical & developmental immunology,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
March 2001, Journal of leukocyte biology,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
April 2017, Journal of the American Society of Nephrology : JASN,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
September 2007, Infection and immunity,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
February 2009, Journal of immunology (Baltimore, Md. : 1950),
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
July 2004, Immunology,
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
September 2006, Clinical immunology (Orlando, Fla.),
YanMei Liang, and Hatice Hasturk, and Jennifer Elliot, and Ansu Noronha, and Xiuping Liu, and Lee M Wetzler, and Paola Massari, and Alpdogan Kantarci, and Harland S Winter, and Francis A Farraye, and Lisa M Ganley-Leal
April 2002, Immunology letters,
Copied contents to your clipboard!