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The basic cellular lesion in CNS of suckling rats treated with Pexid was studied by light and electron miroscopy. The most pronounced abnormality, the formation of various intracytoplasmic inclusions, was found in neurons, astrocytes, oligodendrocytes, ependymal cells, endothelial cells and fibroblasts. These abnormal inclusions were generally membrane-bound, although clearly non-membrane-bound inclusions were occasionally found. The several internal patterns of the inclusions were (1) lamellar, both concentric and parallel, (2) reticular and (3) crystalloid. These alterations were completely reversed following withdrawal of the drug. The structural characteristics of the abnormal inclusions in Pexid-treated animals were similar to those found with certain hypocholesterolemic, neuroleptic, anorectic, and antimalarial drugs. This suggests that the inclusions occurring within the cells of animals treated with any of these drugs may develop in a similar manner, and that the formation of such inclusions is likely to be a form of cellular reaction common to certain metabolic disturbances.
H J Jung, and
K Suzuki
April 1980,
British heart journal,
H J Jung, and
K Suzuki
June 1979,
British journal of experimental pathology,
H J Jung, and
K Suzuki
August 1977,
Drug and therapeutics bulletin,
H J Jung, and
K Suzuki
May 1977,
La Nouvelle presse medicale,
H J Jung, and
K Suzuki
November 1982,
Toxicological European research. Recherche europeenne en toxicologie,
H J Jung, and
K Suzuki
January 1974,
La Nouvelle presse medicale,
H J Jung, and
K Suzuki
March 1974,
Current therapeutic research, clinical and experimental,
H J Jung, and
K Suzuki
March 1978,
La Nouvelle presse medicale,
H J Jung, and
K Suzuki
July 1980,
Irish medical journal,
