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We developed a new apparatus for the measurement of mouse respiratory resistance (Rrs) by an oscillation method. Bronchial responsiveness to methacholine was studied in mice sensitized or not with egg albumin using this apparatus. All of the sensitized mice showed clearly increased bronchial reactivity upon nasal challenge with methacholine compared to normal control mice. The lung obtained from a sensitized mouse showed remarkable contraction of the bronchial smooth muscle, submucosal edema and cell infiltration around the bronchi. These results indicate that mouse Rrs is successfully measured by our newly developed apparatus and suggested that repeated sensitization of mice with allergen render their airway hyperreactive to methacholine.
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
January 1984,
Journal of applied physiology: respiratory, environmental and exercise physiology,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
January 1987,
Bulletin europeen de physiopathologie respiratoire,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
January 1988,
Pulmonary pharmacology,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
September 1990,
The European respiratory journal,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
February 1987,
Nihon Kyobu Shikkan Gakkai zasshi,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
June 1982,
Journal of applied physiology: respiratory, environmental and exercise physiology,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
January 1993,
Archives of environmental health,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
July 1997,
Chest,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
March 1990,
The New England journal of medicine,
M Suko, and
T Koshino, and
M Dohi, and
M Sugiyama, and
H Okudaira, and
K Ito
January 1986,
Clinical allergy,
