The hemodynamics and myocardial contractility were studied in 64 patients with Stages I-II hypertensive disease during 12-week monotherapy with indapamide agents (Fludex, Arifon, Lorvas). Their antihypertensive effect occurred 7-8 days later, with its peak at week 4, and was recorded in 64% patients, by normalizing the above parameters in 48% who had mainly lower or normal ejection and higher peripheral resistance. Improvement of hemodynamic and myocardial contractile parameters was parallel to a reduction in blood pressure.