BIOMAT Database Logo BIOMAT Database Logo

The preventive effects of pulsed electromagnetic fields on diabetic bone loss in streptozotocin-treated rats. 2011

D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Faculty of Biomedical Engineering, Fourth Military Medical University, 17 West Changle Road, Xi'an 710032, China.

The present study was the first report demonstrating that pulsed electromagnetic field (PEMF) could partially prevent bone strength and architecture deterioration and improve the impaired bone formation in streptozotocin-induced diabetic rats. The findings indicated that PEMF might become a potential additive method for inhibiting diabetic osteopenia or osteoporosis. BACKGROUND Diabetes mellitus (DM) can cause various musculoskeletal abnormalities. Optimal therapeutic methods for diabetic bone complication are still lacking. It is essential to develop more effective and safe therapeutic methods for diabetic bone disorders. Pulsed electromagnetic field (PEMF) as an alternative noninvasive method has proven to be effective for treating fracture healing and osteoporosis in non-diabetic conditions. However, the issue about the therapeutic effects of PEMF on diabetic bone complication has not been previously investigated. METHODS We herein systematically evaluated the preventive effects of PEMF on diabetic bone loss in streptozotocin-treated rats. Two similar experiments were conducted. In each experiment, 16 diabetic and eight non-diabetic rats were equally assigned to the control, DM, and DM + PEMF group. DM + PEMF group was subjected to daily 8-h PEMF exposure for 8 weeks. RESULTS In experiment 1, three-point bending test suggested that PEMF improved the biomechanical quality of diabetic bone tissues, evidenced by increased maximum load, stiffness, and energy absorption. Microcomputed tomography analysis demonstrated that DM-induced bone architecture deterioration was partially reversed by PEMF, evidenced by increased Tb.N, Tb.Th, BV/TV, and Conn.D and reduced Tb.Sp and SMI. Serum OC analysis indicated that PEMF partially prevented DM-induced decrease in bone formation. In experiment 2, no significant difference in the bone resorption marker TRACP5b was observed. These biochemical findings were further supported by the dynamic bone histomorphometric parameters BFR/BS and Oc.N/BS. CONCLUSIONS The results demonstrated that PEMF could partially prevent DM-induced bone strength and architecture deterioration and improve the impaired bone formation. PEMF might become a potential additive method for inhibiting diabetic osteoporosis.

UI MeSH Term Description Entries
D008297 Male Males
D010024 Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. Age-Related Osteoporosis,Bone Loss, Age-Related,Osteoporosis, Age-Related,Osteoporosis, Post-Traumatic,Osteoporosis, Senile,Senile Osteoporosis,Osteoporosis, Involutional,Age Related Osteoporosis,Age-Related Bone Loss,Age-Related Bone Losses,Age-Related Osteoporoses,Bone Loss, Age Related,Bone Losses, Age-Related,Osteoporoses,Osteoporoses, Age-Related,Osteoporoses, Senile,Osteoporosis, Age Related,Osteoporosis, Post Traumatic,Post-Traumatic Osteoporoses,Post-Traumatic Osteoporosis,Senile Osteoporoses
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D005269 Femur The longest and largest bone of the skeleton, it is situated between the hip and the knee. Trochanter,Greater Trochanter,Lesser Trochanter,Femurs,Greater Trochanters,Lesser Trochanters,Trochanter, Greater,Trochanter, Lesser,Trochanters,Trochanters, Greater,Trochanters, Lesser
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001696 Biomechanical Phenomena The properties, processes, and behavior of biological systems under the action of mechanical forces. Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic
D013977 Tibia The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally. Tibias
D016723 Bone Remodeling The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS. Bone Turnover,Bone Turnovers,Remodeling, Bone,Turnover, Bone,Turnovers, Bone

Related Publications

D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Pulsed electromagnetic fields inhibit bone loss in streptozotocin-induced diabetic rats.
May 2015, Endocrine,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Effects of extremely low frequency pulsed magnetic fields on diabetic nephropathy in streptozotocin-treated rats.
January 2016, Biomedical engineering online,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Pulsed electromagnetic fields alleviate streptozotocin‑induced diabetic muscle atrophy.
July 2018, Molecular medicine reports,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Modulation of bone loss during disuse by pulsed electromagnetic fields.
July 1991, Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Effect of pulsed electromagnetic fields on bone formation and bone loss during limb lengthening.
June 1996, Bone,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Pulsed electromagnetic fields accelerate wound healing in the skin of diabetic rats.
May 2010, Bioelectromagnetics,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss.
November 2003, International journal of molecular medicine,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Effects of static magnetic and pulsed electromagnetic fields on bone healing.
January 1997, The International journal of adult orthodontics and orthognathic surgery,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Autoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile rats.
January 1993, Archives of oral biology,
D Jing, and J Cai, and G Shen, and J Huang, and F Li, and J Li, and L Lu, and E Luo, and Q Xu
Diabetic characteristics and alveolar bone loss in streptozotocin- and streptozotocin-nicotinamide-treated rats with periodontitis.
December 2014, Journal of periodontal research,
Copied contents to your clipboard!