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Experimental models for hyper-beta-lipoproteinemia were established in rats and the effects of certain hypolipidemic drugs were studied with these models. In the hyperlipemia induced in rats by feeding a high cholesterol diet, Y-9738 [ethyl 2(4-chlorophenyl)-5-ethoxy-4-oxazoleacetate] produced a dose-dependent reduction of serum cholesterol: such hypolipidemic activity was estimated to be about 7 times as great as that of clofibrate. On the other hand, clofibrate induced hepatomegaly at 100 mg/kg, whereas Y-9738 did not at this dosage, which is about 10 times the effective dose. Hyperlipemia induced by high cholesterol and thiouracil was characterized by increased beta-lipoprotein (heparin-calcium and disc electrophoresis). In this model, Y-9738 showed a dose-dependent lowering effect on beta-lipoprotein cholesterol with a marked decrease in the beta/alpha lipoprotein ratio. A tendency was noted for alpha-lipoprotein to be increased. In contrast, clofibrate exerted no effect on this hyper-beta-lipoproteinemia. These results suggest that the above models may be of value in exploring hyper-beta-lipoproteinemia and that Y-9738 may be more useful than clofibrate in the therapy of hyperlipemia.
T Kobayakawa, and
K Osuga, and
H Yasuda
July 1974,
Indian pediatrics,
T Kobayakawa, and
K Osuga, and
H Yasuda
October 1969,
Neurology,
T Kobayakawa, and
K Osuga, and
H Yasuda
June 1979,
Clinical genetics,
T Kobayakawa, and
K Osuga, and
H Yasuda
September 1965,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
T Kobayakawa, and
K Osuga, and
H Yasuda
January 1970,
Archives belges de dermatologie et de syphiligraphie,
T Kobayakawa, and
K Osuga, and
H Yasuda
October 1969,
Minerva pediatrica,
T Kobayakawa, and
K Osuga, and
H Yasuda
April 1975,
Clinical chemistry,
T Kobayakawa, and
K Osuga, and
H Yasuda
June 1983,
American journal of medical genetics,
T Kobayakawa, and
K Osuga, and
H Yasuda
May 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
T Kobayakawa, and
K Osuga, and
H Yasuda
October 1978,
Pediatrics,
