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A method of determination of sulbaktam in human serum by capillary isotachophoresis with the use of a conductivity detector was worked out. Prior to the proper analysis, a pretreatment of the sample of serum was carried out by extracting sulbaktam to butyl acetate. The total yield of the proposed analytical procedure with an extraction first stage approaches 94%. The smallest determinable amount of the sample corresponds to 1 micrograms of sulbaktam in 1 ml of serum. The reported method was employed to evaluate the samples of sera of volunteers after intravenous administration of the dosage form sulbaktam-ampicillin (VUFB) and the foreign pharmaceutical preparation Unasyn (Pfizer). Statistically insignificant differences in pharmacokinetic parameters have confirmed that the preparations are highly bio-equivalent.
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
December 1995,
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
June 1995,
Die Pharmazie,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
June 1999,
Journal of chromatography. B, Biomedical sciences and applications,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
November 2000,
Die Pharmazie,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
August 1999,
Die Pharmazie,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
September 1997,
Electrophoresis,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
April 2008,
Electrophoresis,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
March 2000,
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
June 1980,
Journal of chromatography,
I Jelínek, and
H Krejcírová, and
J Dohnal, and
Z Roubal, and
V Holá, and
V Rejholec
December 1985,
Journal of chromatography,
