Biomaterial Database

Cytogenetic analysis in patients with myelodysplastic syndrome. 1990

N Hu, and M Bian

Cancer Institute, CAMS, Beijing.

Forty-six patients with myelodysplastic syndrome (MDS) were studied. Chromosomal abnormalities were observed in 20 of the 46 patients (43%). Abnormalities of chromosome No. 5 occurred in 6 patients (13%); four of them had a deletion of the long arm of this chromosome [del (5q)]. Four patients had monosomy 7 (8.6%), and six patients had trisomy 8 (13%). Our results suggest that chromosomal abnormalities, deletion (5q), monosomy 7 and trisomy 8, might play important roles in the pathogenesis of MDS.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009006	Monosomy	The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.	Monosomies
D009190	Myelodysplastic Syndromes	Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.	Dysmyelopoietic Syndromes,Hematopoetic Myelodysplasia,Dysmyelopoietic Syndrome,Hematopoetic Myelodysplasias,Myelodysplasia, Hematopoetic,Myelodysplasias, Hematopoetic,Myelodysplastic Syndrome,Syndrome, Dysmyelopoietic,Syndrome, Myelodysplastic,Syndromes, Dysmyelopoietic,Syndromes, Myelodysplastic
D002869	Chromosome Aberrations	Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.	Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D002872	Chromosome Deletion	Actual loss of portion of a chromosome.	Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D002895	Chromosomes, Human, Pair 5	One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).	Chromosome 5
D002897	Chromosomes, Human, Pair 7	A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.	Chromosome 7
D002898	Chromosomes, Human, Pair 8	A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.	Chromosome 8
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults