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Hypertension caused by deoxycorticosterone-salt (DOC-salt) may involve enhanced sympathetic tone and some diuretics may exert their antihypertensive action by modulating presynaptic adrenergic sensitivity. This study analyzes the noradrenergic sensitivity of the perfused mesentery isolated from DOC-salt hypertensive rats treated or not with chlorthalidone. Chlorthalidone treatment reduced arterial hypertension in DOC-salt treated rats (from 160 +/- 7 to 127 +/- 5 mmHg). The diuretic completely prevented the increase in sympathetic tone and blunted the decreased vagal tone observed in DOC-salt rats. Norepinephrine-induced vasoconstriction was enhanced in perfused mesenteries isolated from DOC-salt rats. This alteration was attenuated in preparations from chlorthalidone-treated DOC-salt animals. Blockade of neuronal catecholamine uptake using cocaine did not change these responses. These data suggest that chlorthalidone reduces the vascular hyperresponsiveness to catecholamines observed in DOC-salt treated hypertensive rats.
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
January 1981,
Hypertension (Dallas, Tex. : 1979),
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
February 1988,
The Tohoku journal of experimental medicine,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
January 1996,
Pharmacological research,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
July 1981,
The Journal of pharmacy and pharmacology,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
January 1985,
Clinical and experimental hypertension. Part A, Theory and practice,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
January 1982,
Clinical and experimental hypertension. Part A, Theory and practice,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
November 2002,
Clinical and experimental pharmacology & physiology,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
March 1997,
Journal of hypertension,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
January 1971,
Il Policlinico. Sezione chirurgica,
M N Musso, and
E C Vasquez, and
F B Carvalhinho, and
N S Bissoli, and
A M Cabral
May 1983,
Canadian journal of physiology and pharmacology,
