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The comparative inhibitory potency of papaverine and Ro 20-1724 (4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone) on cyclic AMP-phosphodiesterase (cAMP-PDE) and cyclic GMP-phosphodiesterase (cGMP-PDE) activities and their effect on the levels of cAMP and cGMP were examined in psoriatic epidermis. At concentrations of 5 X 10(-4) M, papaverine inhibited the hydrolysis of both cAMP and cGMP by either the low or high Km psoriatic epidermal PDE nearly 100% (p less than .0001) while Ro 20-1724 selectively inhibited the hydrolysis of cAMP 94% (p less than .0001) but had no significant effect on cGMP hydrolysis. When keratomed psoriatic epidermal slices were incubated in 5 X 10(-4) M papaverine or Ro 20-1724 the tissue levels of cAMP were increased 343% or 1395% respectively (p less than .001) with no concomitant change in the levels of cGMP. Selective inhibition of cAMP hydrolysis by Ro 20-1724 and its greater effectiveness in elevating cAMP levels in slices of psoriatic epidermis is one explanation for its clinical superiority in treating psoriatic lesions.
L J Rusin, and
E A Duell, and
J J Voorhees
January 1998,
Life sciences,
L J Rusin, and
E A Duell, and
J J Voorhees
January 1979,
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L J Rusin, and
E A Duell, and
J J Voorhees
December 1971,
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L J Rusin, and
E A Duell, and
J J Voorhees
January 1981,
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L J Rusin, and
E A Duell, and
J J Voorhees
June 1985,
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L J Rusin, and
E A Duell, and
J J Voorhees
September 1975,
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L J Rusin, and
E A Duell, and
J J Voorhees
January 1982,
Dermatologica,
L J Rusin, and
E A Duell, and
J J Voorhees
July 1972,
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L J Rusin, and
E A Duell, and
J J Voorhees
January 1990,
Molecular pharmacology,
L J Rusin, and
E A Duell, and
J J Voorhees
January 1974,
Acta dermato-venereologica,
