Biomaterial Database

Does feedback regulation of pancreatic enzyme secretion by duodenal trypsin exist in cholecystectomized patients? 1990

J Długosz, and A Gabryelewicz, and U R Fölsch, and A Czajkowski

Department of Gastroenterology, Medical Academy, Białystok, Poland.

Recent studies have supported the existence of a feedback regulation of pancreatic enzyme secretion in man. The aim of present study was to evaluate whether a feedback regulation of pancreatic enzyme secretion exists in cholecystectomized patients. The study was carried out in 12 healthy volunteers and in 6 cholecystectomized patients, 7-14 years (mean 9 years) after the operation. Pancreatic secretion was stimulated by intraduodenal infusion of L-phenylalanine (100 mmo 1.1-1). The calculated outputs of pancreatic alpha-amylase and lipase were estimated. The feedback phenomenon was studied using consecutive intraduodenal infusion of trypsin (300 mg/h) and aprotinin (1.5 x 10(6) KIU/30 min). In 6 healthy persons, the infusion of trypsin caused a significant decrease (35-45%) in phenylalaninestimulated alpha-amylase and lipase outputs (p less than 0.05). This effect was completely reversed by intraduodenal aprotinin infusion. In contrast, the increase or the inhibition of tryptic activity in the duodenum was without any effect on pancreatic secretion in cholecystectomized patients. A feedback control of pancreatic secretion could not be demonstrated in patients 6-14 years after cholecystectomy.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010179	Pancreas	A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D002763	Cholecystectomy	Surgical removal of the GALLBLADDER.	Cholecystectomies
D004386	Duodenum	The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.	Duodenums
D005246	Feedback	A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.	Feedbacks
D005260	Female		Females
D005704	Gallbladder	A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.	Gallbladders
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths