Protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification: rabbit model. 2010

Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
Ophthalmology Department, KaplanMedical Center, Rehovot, Israel.

OBJECTIVE To evaluate the protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification in a rabbit model. METHODS Harlan Biotech Israel and Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel. METHODS Experimental study. METHODS Rabbit eyes were randomly assigned to 3 equally sized groups. Endothelial cell counts were performed in all eyes before initiation of the study. The aqueous humor was completely replaced by Biolon (sodium hyaluronate 1.0%) in Group A, by a combination of Viscoat (sodium chondroitin sulfate 4.0%-sodium hyaluronate 3.0%) and Provisc (sodium chondroitin sulfate 1.0%) using the soft-shell technique in Group B, and by a combination of Visiol (sodium hyaluronate 2.0%-mannitol 0.5%) and Biolon using the soft-shell technique in Group C. The eyes were exposed to alternating 10 seconds of phacoemulsification and a 10-second pause until a total exposure time of 2.5 minutes elapsed. Endothelial cell counts were repeated 3 days after surgery. RESULTS The study used 18 rabbit eyes, 6 in each group. Group A had the highest endothelial cell loss (13%) followed by Group B (7%), and Group C (4%). The difference in cell loss between Group C and Group A was statistically significant (P = .037). CONCLUSIONS The study showed the efficiency and advantages of the soft-shell technique using the combination of Visiol and Biolon over Biolon alone.

UI MeSH Term Description Entries
D009883 Ophthalmic Solutions Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS. Eye Drop,Eyedrop,Eyedrops,Ophthalmic Solution,Eye Drops,Drop, Eye,Drops, Eye,Solution, Ophthalmic,Solutions, Ophthalmic
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002452 Cell Count The number of CELLS of a specific kind, usually measured per unit volume or area of sample. Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D002809 Chondroitin Sulfates Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate. Chondroitin 4-Sulfate,Chondroitin 6-Sulfate,Chondroitin Sulfate A,Chondroitin Sulfate C,Blutal,Chondroitin 4-Sulfate, Aluminum Salt,Chondroitin 4-Sulfate, Potassium Salt,Chondroitin 6-Sulfate, Potassium Salt,Chondroitin 6-Sulfate, Sodium Salt,Chondroitin Sulfate,Chondroitin Sulfate 4-Sulfate, Sodium Salt,Chondroitin Sulfate, Calcium Salt,Chondroitin Sulfate, Iron (+3) Salt,Chondroitin Sulfate, Iron Salt,Chondroitin Sulfate, Potassium Salt,Chondroitin Sulfate, Sodium Salt,Chondroitin Sulfate, Zinc Salt,Chonsurid,Sodium Chondroitin Sulfate,Translagen,Chondroitin 4 Sulfate,Chondroitin 4 Sulfate, Aluminum Salt,Chondroitin 4 Sulfate, Potassium Salt,Chondroitin 6 Sulfate,Chondroitin 6 Sulfate, Potassium Salt,Chondroitin 6 Sulfate, Sodium Salt,Chondroitin Sulfate 4 Sulfate, Sodium Salt,Chondroitin Sulfate, Sodium,Sulfate, Chondroitin,Sulfate, Sodium Chondroitin,Sulfates, Chondroitin
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug
D004728 Endothelium, Corneal Single layer of large flattened cells covering the surface of the cornea. Anterior Chamber Epithelium,Corneal Endothelium,Endothelium, Anterior Chamber,Epithelium, Anterior Chamber,Anterior Chamber Endothelium
D006820 Hyaluronic Acid A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA. Amo Vitrax,Amvisc,Biolon,Etamucine,Healon,Hyaluronan,Hyaluronate Sodium,Hyvisc,Luronit,Sodium Hyaluronate,Acid, Hyaluronic,Hyaluronate, Sodium,Vitrax, Amo
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D055675 Viscosupplements Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS. Visco Supplements,Viscosupplement,Supplements, Visco
D055954 Corneal Endothelial Cell Loss Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging. Corneal Endothelial Cell Damage,Endothelial Cell Loss, Corneal

Related Publications

Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
May 2024, Clinical & experimental ophthalmology,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
December 2022, Journal of cataract and refractive surgery,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
January 2009, Japanese journal of ophthalmology,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
June 2006, Journal of cataract and refractive surgery,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
January 2020, Journal of ophthalmology,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
February 2020, Journal of cataract and refractive surgery,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
December 2016, Current eye research,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
November 2014, Journal of cataract and refractive surgery,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
June 2013, Current eye research,
Shmuel Ben-Eliahu, and Kfir Tal, and Asher Milstein, and Tal Levin-Harrus, and Nati Ezov, and Guy Kleinmann
February 2022, Translational vision science & technology,
Copied contents to your clipboard!