Caffeine and brain development in very preterm infants. 2010

Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
Royal Women's Hospital, University of Melbourne, Parkville, Victoria, Australia. lwd@unimelb.edu.au

OBJECTIVE Caffeine improves neurological outcome in very preterm infants, but the mechanisms responsible for this neurological benefit are unknown. The objective of this study was to assess whether caffeine influenced brain macro- or microstructural development in preterm infants. METHODS Seventy preterm infants <1,251 g birthweight randomly allocated to either caffeine (n = 33) or placebo (n = 37) underwent brain magnetic resonance imaging (MRI) at term-equivalent age; white and gray matter abnormalities were qualitatively scored, global and regional brain volumes were measured, and white matter microstructure was evaluated using diffusion-weighted imaging. RESULTS There were no significant differences between the groups in the extent of white matter or gray matter abnormality, or in global or regional brain volumes. In contrast, although only available in 28 children, caffeine exposure was associated with reductions in the apparent diffusion coefficient, and radial and axial diffusivity with the greatest impact in the superior brain regions. The alterations in diffusion measures were not mediated by lowering the rate of lung injury, known as bronchopulmonary dysplasia. CONCLUSIONS These diffusion changes are consistent with improved white matter microstructural development in preterm infants who received caffeine.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007234 Infant, Premature A human infant born before 37 weeks of GESTATION. Neonatal Prematurity,Premature Infants,Preterm Infants,Infant, Preterm,Infants, Premature,Infants, Preterm,Premature Infant,Prematurity, Neonatal,Preterm Infant
D008297 Male Males
D009413 Nerve Fibers, Myelinated A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves. A Fibers,B Fibers,Fiber, Myelinated Nerve,Fibers, Myelinated Nerve,Myelinated Nerve Fiber,Myelinated Nerve Fibers,Nerve Fiber, Myelinated
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001997 Bronchopulmonary Dysplasia A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS. Dysplasia, Bronchopulmonary
D002110 Caffeine A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. 1,3,7-Trimethylxanthine,Caffedrine,Coffeinum N,Coffeinum Purrum,Dexitac,Durvitan,No Doz,Percoffedrinol N,Percutaféine,Quick-Pep,Vivarin,Quick Pep,QuickPep
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000697 Central Nervous System Stimulants A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. Analeptic,Analeptic Agent,Analeptic Drug,Analeptics,CNS Stimulant,CNS Stimulants,Central Nervous System Stimulant,Central Stimulant,Analeptic Agents,Analeptic Drugs,Central Stimulants,Agent, Analeptic,Agents, Analeptic,Drug, Analeptic,Drugs, Analeptic,Stimulant, CNS,Stimulant, Central,Stimulants, CNS,Stimulants, Central

Related Publications

Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
April 2011, Journal of paediatrics and child health,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
October 2020, Respiratory physiology & neurobiology,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
December 2021, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
January 2019, NeuroImage. Clinical,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
July 2016, Early human development,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
November 2015, World journal of clinical pediatrics,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
August 2010, The Journal of pediatrics,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
December 2001, Journal of paediatrics and child health,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
November 2017, American journal of respiratory and critical care medicine,
Lex W Doyle, and Jeanie Cheong, and Rod W Hunt, and Katherine J Lee, and Deanne K Thompson, and Peter G Davis, and Sandra Rees, and Peter J Anderson, and Terrie E Inder
November 2023, Neurology,
Copied contents to your clipboard!