BIOMAT Database Logo BIOMAT Database Logo

Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine. 2011

Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.

Infection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS), is responsible for acute and postinfectious complications, including rheumatic fever and rheumatic heart disease (RHD). RHD is a global health burden, and Australia's indigenous population has one of the highest incidences of RHD worldwide. A potential peptide (J14) vaccine candidate has been previously identified from the C-terminal region of the M protein. However, such peptide-based vaccine development is hampered by a lack of carriers and adjuvants suitable for humans use. We have developed a fully synthetic peptide subunit vaccine candidate based on polyacrylate dendritic polymer. Intranasal administration of this nanoparticulate construct without additional adjuvant induced J14-specific IgG, which was also capable of in vitro opsonization of GAS, highlighting the potential of self-adjuvanting polyacrylate nanoparticle-based construct as a peptide vaccine delivery platform that may afford promising opportunities for treating systemic GAS infection. BACKGROUND Polyacrylate dendrimers offer a unique approach to a nasally administered vaccine for addressing rheumatic heart disease. This paper describes the delivery of the J14 peptide, a C-terminal derivative of M-protein in group A Streptococcus.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007114 Immunization Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow). Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D009895 Opsonin Proteins Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate. Opsonin,Opsonin Protein,Opsonins,Protein, Opsonin
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000180 Acrylic Resins Polymers of high molecular weight which are derived from acrylic acid, methacrylic acid or other related compounds and are capable of being molded and then hardened to form useful components. Acrylic Resin,Resin, Acrylic,Resins, Acrylic
D000281 Administration, Intranasal Delivery of medications through the nasal mucosa. Drug Administration, Intranasal,Administration, Intranasal Drug,Administration, Nasal,Intranasal Administration,Intranasal Drug Administration,Administrations, Intranasal,Administrations, Intranasal Drug,Administrations, Nasal,Drug Administrations, Intranasal,Intranasal Administrations,Intranasal Drug Administrations,Nasal Administration,Nasal Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013290 Streptococcal Infections Infections with bacteria of the genus STREPTOCOCCUS. Group A Strep Infection,Group A Streptococcal Infection,Group A Streptococcal Infections,Group B Strep Infection,Group B Streptococcal Infection,Group B Streptococcal Infections,Infections, Streptococcal,Infection, Streptococcal,Streptococcal Infection

Related Publications

Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Poly(hydrophobic amino acid)-Based Self-Adjuvanting Nanoparticles for Group A Streptococcus Vaccine Delivery.
March 2021, Journal of medicinal chemistry,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system.
October 2019, European journal of medicinal chemistry,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Lipid-core-peptide system for self-adjuvanting synthetic vaccine delivery.
January 2011, Methods in molecular biology (Clifton, N.J.),
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS).
April 2013, Vaccine,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Self-adjuvanting vaccine against group A streptococcus: application of fibrillized peptide and immunostimulatory lipid as adjuvant.
November 2014, Bioorganic & medicinal chemistry,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Structure-Activity Analysis of Cyclic Multicomponent Lipopeptide Self-Adjuvanting Vaccine Candidates Presenting Group A Streptococcus Antigens.
May 2020, Journal of medicinal chemistry,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus.
September 2019, ACS medicinal chemistry letters,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Group A streptococcal vaccine delivery by immunization with a self-adjuvanting M protein-based lipid core peptide construct.
May 2004, The Indian journal of medical research,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system.
June 2014, Drug delivery and translational research,
Mehfuz Zaman, and Mariusz Skwarczynski, and Jessica M Malcolm, and Carl N Urbani, and Zhongfan Jia, and Michael R Batzloff, and Michael F Good, and Michael J Monteiro, and Istvan Toth
Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties.
March 2017, Chembiochem : a European journal of chemical biology,
Copied contents to your clipboard!