-transparent.png){kind=logo}
Several animal models of arthritis are produced using complete Freund's adjuvant (CFA) alone or with collagen as an arthritogen. Successful induction of arthritis is reported to require that the adjuvant mixture be administered by intradermal or subcutaneous routes. The resulting arthritis is caused by primarily cellular immune responses. Data presented in this paper show that giving CFA by intraperitoneal (I.P.) inoculation results in a humoral autoimmune response, with no obvious signs of arthritis. This humoral autoimmune response is characterized by production of autoantibodies to nuclear and cytoplasmic antigens, elevated levels of circulating immune complexes, and in approximately 25% of mice, rheumatoid factor.
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
February 2012,
Lupus,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
March 1989,
Laboratory animal science,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
May 1965,
Laboratory investigation; a journal of technical methods and pathology,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
March 2001,
The Journal of the Association of Physicians of India,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
May 2002,
The Journal of the Association of Physicians of India,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
October 1976,
Experimental eye research,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
January 1971,
Allergie und Immunologie,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
January 1964,
The Journal of allergy,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
February 1999,
Experimental cell research,
P T Fawcett, and
S B Dubbs, and
L B Fawcett, and
R A Doughty
December 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
