Biomaterial Database

Anticariogenic effect of fluoridated milk and water in rats. 1990

J Bánóczy, and B Ritlop, and G Solymosi, and A Gombik, and A Adatia

Department of Conservative Dentistry, Semmelweis Medical University, Budapest, Hungary.

The aim of the study was to get further experimental data on the anticariogenic effect of sodium fluoride (NaF) when administered in milk or water. Thirty six weanling Osborne-Mendel rats were divided into two experimental groups (A, B) of 12 rats each and two control groups (C, D) of six rats each. During the experimental period of four weeks all animals were superinfected with Strep. mutans (NCTC 10449), kept in an automatic feeding machine and given a cariogenic diet (MIT 301). Group A received sodium fluoride (NaF) in water (15 ppm) and group B in ultra high temperature treated milk. Groups C and D respectively received plain milk and distilled water. Group A did not show significantly lower caries reduction compared with the control groups. Group B had significantly the lowest caries scores compared with all other groups. Scores in group C (plain milk) were lower than those in groups D (plain water). The results suggest that the anticariogenic effect of NaF is more pronounced when the vehicle is milk instead of water.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008892	Milk	The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals.	Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D003731	Dental Caries	Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	Caries, Dental,Carious Lesions,Dental Cavities,Dental Cavity,Dental Decay,Dental White Spots,Carious Dentin,Decay, Dental,Dental White Spot,White Spot, Dental,White Spots, Dental,Carious Dentins,Carious Lesion,Cavities, Dental,Cavity, Dental,Dentin, Carious,Dentins, Carious,Lesion, Carious,Lesions, Carious,Spot, Dental White,Spots, Dental White
D004037	Diet, Cariogenic	A consistent pattern of food and drink consumption that contributes to the development and advancement of DENTAL CARIES.	Cariogenic Diet,Cariogenic Diets,Diets, Cariogenic
D004326	Drinking	The consumption of liquids.	Water Consumption,Water Intake,Drinkings
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001682	Biological Availability	The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.	Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities
D012969	Sodium Fluoride	A source of inorganic fluoride which is used topically to prevent dental caries.	Fluoristat,Ossin,Zymafluor,Fluoride, Sodium,Fluorides, Sodium,Fluoristats,Ossins,Sodium Fluorides,Zymafluors
D014867	Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Hydrogen Oxide