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A decrease in the activity of the enzyme cytidine 3',5'-monophosphate (cyclic CMP) phosphodiesterase was noted in the regenerating liver of young rats as early as 8 hours after partial hepatectomy, with a maximum decrease occurring 12 hours after the surgery. In comparison, in old rats which showed a slower liver growth, the maximum decrease in the activity of cyclic CMP phosphodiesterase was smaller and occurred at a much later time (2 days after surgery). A similar decrease in the enzyme activity was observed in the fetal liver of guinea pigs. These findings suggest that regulation of tissue concentration of cyclic CMP may be crucial for the regeneration and development of the liver.
M Shoji, and
N L Brackett, and
J F Kuo
September 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M Shoji, and
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J F Kuo
February 1973,
Cancer research,
M Shoji, and
N L Brackett, and
J F Kuo
March 1980,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Shoji, and
N L Brackett, and
J F Kuo
January 1983,
The International journal of biochemistry,
M Shoji, and
N L Brackett, and
J F Kuo
November 1984,
Biochemical pharmacology,
M Shoji, and
N L Brackett, and
J F Kuo
February 1977,
Medical biology,
M Shoji, and
N L Brackett, and
J F Kuo
June 1974,
Analytical biochemistry,
M Shoji, and
N L Brackett, and
J F Kuo
January 1972,
Analytical biochemistry,
M Shoji, and
N L Brackett, and
J F Kuo
November 1981,
Acta pharmacologica et toxicologica,
M Shoji, and
N L Brackett, and
J F Kuo
January 1975,
Cancer research,
