-transparent.png){kind=logo}
Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration. Here we show that the rearrangement of the bcl-2 gene occurs in a significant fraction (approximately of 10%) of B cell CLL. In all cases analyzed, breakpoints on chromosome 18 clustered at the 5' flanking region of the bcl-2 gene, and no rearrangements were found at the major or minor breakpoint clustering region (3' region of bcl-2 gene) typical of the t(14;18) chromosome translocation. All of the rearranged bcl-2 genes were juxtaposed with the Ig lambda or K genes in a head-to-head configuration. These results imply that the bcl-2 gene is preferentially linked to the IgL genes in CLL and could function in leukemogenesis.
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
April 1989,
Proceedings of the National Academy of Sciences of the United States of America,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
November 2005,
Blood,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
May 1990,
American journal of clinical pathology,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
March 1992,
Oncogene,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
April 2009,
Cancer science,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
January 1992,
Current topics in microbiology and immunology,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
September 1989,
Oncogene,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
January 2019,
Methods in molecular biology (Clifton, N.J.),
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
June 2003,
Current treatment options in oncology,
M Adachi, and
A Tefferi, and
P R Greipp, and
T J Kipps, and
Y Tsujimoto
October 2000,
Cancer research,
