BIOMAT Database Logo BIOMAT Database Logo

Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation. 2011

Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Department of Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.

OBJECTIVE To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation. METHODS Retrospective, case-control study. METHODS University hospital, IVF center. METHODS Seventeen women with OHSS and 61 controls. METHODS None. METHODS FF and serum EG-VEGF and VEGF concentrations, IVF outcome. RESULTS FF and serum EG-VEGF concentrations showed a significant negative correlation with serum E(2) concentration on the day of hCG administration. FF, but not serum, VEGF concentrations also showed a significant negative correlation with serum E(2) concentrations on hCG day. The FF EG-VEGF, FF VEGF, and serum EG-VEFG concentrations were significantly lower in the OHSS group than in the non-OHSS group. There was no significant difference in serum VEGF concentrations. Among FF and serum EG-VEGF and VEGF concentrations, only FF EG-VEGF concentrations were significantly lower in patients with moderate OHSS than in those with mild OHSS. CONCLUSIONS FF and serum EG-VEGF concentrations may predict OHSS occurrence. Furthermore, FF EG-VEGF concentrations were significantly correlated with OHSS severity; thus, EG-VEGF appears to be more valuable than VEGF for predicting OHSS.

UI MeSH Term Description Entries
D007246 Infertility A reduced or absent capacity to reproduce. Sterility,Reproductive Sterility,Sterility, Reproductive,Sub-Fertility,Subfertility
D009994 Osmolar Concentration The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent. Ionic Strength,Osmolality,Osmolarity,Concentration, Osmolar,Concentrations, Osmolar,Ionic Strengths,Osmolalities,Osmolar Concentrations,Osmolarities,Strength, Ionic,Strengths, Ionic
D010062 Ovulation Induction Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum. Ovarian Stimulation,Ovarian Stimulations,Stimulation, Ovarian,Stimulations, Ovarian
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D004624 Embryo Transfer The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO. Blastocyst Transfer,Tubal Embryo Transfer,Tubal Embryo Stage Transfer,Embryo Transfers,Transfer, Embryo,Transfers, Embryo
D005260 Female Females
D005307 Fertilization in Vitro An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro. Test-Tube Fertilization,Fertilizations in Vitro,In Vitro Fertilization,Test-Tube Babies,Babies, Test-Tube,Baby, Test-Tube,Fertilization, Test-Tube,Fertilizations, Test-Tube,In Vitro Fertilizations,Test Tube Babies,Test Tube Fertilization,Test-Tube Baby,Test-Tube Fertilizations
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Severe ovarian hyperstimulation syndrome: serum and ascitic fluid concentrations of vascular endothelial growth factor.
April 1997, Current opinion in obstetrics & gynecology,
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome.
March 2004, Human reproduction (Oxford, England),
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Serum vascular endothelial growth factor concentrations in in vitro fertilization cycles predict the risk of ovarian hyperstimulation syndrome.
February 1999, Fertility and sterility,
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Vascular endothelial growth factor, interleukin-6 and interleukin-2 in serum and follicular fluid of patients with ovarian hyperstimulation syndrome.
March 2002, European journal of obstetrics, gynecology, and reproductive biology,
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Follicular fluid levels of vascular endothelial growth factor. Are they predictive markers for ovarian hyperstimulation syndrome?
February 1999, The Journal of reproductive medicine,
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Vascular endothelial growth factor levels in serum and plasma from patients undergoing controlled ovarian hyperstimulation for IVF.
March 2007, Human reproduction (Oxford, England),
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma.
January 2003, Clinical cancer research : an official journal of the American Association for Cancer Research,
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Serum concentration of vascular endothelial growth factor cannot predict the course of severe ovarian hyperstimulation syndrome.
January 1998, Human reproduction (Oxford, England),
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Serum vascular endothelial growth factor levels are poorly predictive of subsequent ovarian hyperstimulation syndrome in highly responsive women undergoing assisted conception.
December 2002, Fertility and sterility,
Min-Zhi Gao, and Xiao-Ming Zhao, and Zhao-Gui Sun, and Yan Hong, and Lei-Wen Zhao, and Hui-Qin Zhang
Vascular endothelial growth factor, polycystic ovary syndrome, and ovarian hyperstimulation syndrome.
December 2002, Fertility and sterility,
Copied contents to your clipboard!