-transparent.png){kind=logo}
Pseudomonas exotoxin A, an ADP-ribosylating toxin produced by Pseudomonas aeruginosa, has been shown to stimulate the proliferation of murine thymocytes, which requires the participation of accessory cells. This requirement for accessory cells can be replaced by supernatant from adherent peritoneal exudate cells that have been stimulated with exotoxin A. Antibody to exotoxin A inhibits the induction of the thymocyte mitogenic activity from adherent peritoneal macrophages. However, antibody to exotoxin A had no effect on the thymocyte proliferation if the antibody was added to supernatant which contained thymocyte mitogenic activity. The thymocyte mitogenic activity was associated with a protein or protein complex with a molecular mass of greater than 10,000 daltons. D10 bioassays indicated the presence of interleukin-1 (IL-1) in the supernatant. Antibody to IL-1 inhibited the ability of supernatant to induce thymocytes to proliferate. Therefore, these data suggest that Pseudomonas exotoxin A can stimulate the production of IL-1 from adherent peritoneal cells, which induces murine thymocytes to proliferate.
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
January 1988,
Infection and immunity,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
July 1984,
Infection and immunity,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
March 1978,
Infection and immunity,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
May 1982,
Journal of molecular biology,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
January 1992,
Targeted diagnosis and therapy,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
June 1980,
The New England journal of medicine,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
October 1982,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
May 1980,
Infection and immunity,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
February 2003,
Cellular immunology,
M L Misfeldt, and
P K Legaard, and
S E Howell, and
M H Fornella, and
R D LeGrand
April 1987,
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
