OBJECTIVE The aim of this study was the clinical evaluation of three denture cushion adhesives and whether the results were correlated to Kapur Index for denture-supporting tissues. BACKGROUND Various types of denture adhesives are used among denture patients. However, information on the clinical behaviour of denture cushions is limited. METHODS Thirty edentulous patients had their denture-supporting tissues scored by Kapur Index and their old dentures replaced. They received three brands of denture cushion adhesives (Fittydent(®) , Protefix(®) and Seabond(®)) and were instructed to use them in a sequence according to the group they were randomly assigned to. Each brand of adhesive was used for 48 h on the lower denture according to the manufacturer's suggestions. After each brand was used, participants spent 24 h without applying any sort of adhesive. Finally, a questionnaire evaluating and comparing the performance of each brand was filled out. RESULTS Denture adhesives generally improved patient satisfaction and masticatory ability, especially in participants with poor Kapur Index and those who reported a poor retention of their old dentures. CONCLUSIONS Fittydent(®) was the most preferred adhesive, showing the best retention and the longest duration of its effect, but also reported as difficult to remove from the denture-bearing area.