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A new technology for isolation of medicinal balneological preparations from mineral waters has been developed. It is based on the extraction of biologically active compounds (BAC) from mineral waters with ethanol following oxidative hydrolysis and water vapour distillation. This technology has no analogs both in this country and abroad. Unlike ordinary balneological medicines, those obtained by the new method do not contain inorganic matrix, show higher activity, and remain stable for a longer period. The primary composition of BACs isolated by the above technology was studied using solid-phase extraction and chromatomass-spectrometry. Analysis of Extramine, a medicinal preparation from Novonukutskaya hydrogen sulfide mineral water (Siberian Matsesta), allowed to identify active components responsible for its therapeutic effects and elucidate mechanisms of their action. The 15-year-long experience with practical application of BACs obtained with the help of the new technology has demonstrated that they possesses antiallergic, antiviral, and analeptic activities. These compounds increase general resistance of the organism to infection, promote removal of toxic substances, accelerate wound and injury healing, and prevent the development of herpes infection.
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 1979,
Fysiatricky a reumatologicky vestnik,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 2013,
Srpski arhiv za celokupno lekarstvo,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 2006,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
March 1977,
Vrachebnoe delo,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 1974,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 1972,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 1973,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 2022,
Critical reviews in food science and nutrition,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
August 1989,
Gigiena i sanitariia,
G M Shpeĭzer, and
V A Khutorianskiĭ, and
A I Smirnov, and
V A Rodionova, and
L A Mineeva, and
G G Iushkov, and
N A Malyshkina, and
V V Igumen'sheva, and
O G Shchukina
January 1948,
Zeitschrift fur physikalische Therapie, Bader- und Klimaheilkunde,
