-transparent.png){kind=logo}
A typical All-in-One (AIO) parenteral nutrition mixture in a 3-litre polymeric infusion bag will consist of lipid emulsion, amino acids, glucose, electrolytes, trace elements and vitamins. This varied mixture of chemical entities provides the potential for a number of chemical and physicochemical interactions that can compromise the clinical safety and efficacy of the product. The destabilisation of the lipid emulsion in the presence of electrolytes is a major problem. Although a predictive equation for the maximum concentrations of mono-, di- and trivalent ions causing instability has been proposed, it is too simplistic to be of significant value. The reasons for this are discussed as well as the stability implications of other additives to the parenteral nutrition mixture.
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
February 2022,
JPEN. Journal of parenteral and enteral nutrition,
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
March 2019,
Molecules (Basel, Switzerland),
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
September 1998,
Nutrition (Burbank, Los Angeles County, Calif.),
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
January 1979,
Chemotherapy,
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
January 2016,
Einstein (Sao Paulo, Brazil),
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
June 2023,
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
June 1999,
Clinical nutrition (Edinburgh, Scotland),
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
May 2007,
Current opinion in clinical nutrition and metabolic care,
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
September 2021,
Pharmaceutics,
M I Barnett, and
A G Cosslett, and
J R Duffield, and
D A Evans, and
S B Hall, and
D R Williams
February 2019,
JPEN. Journal of parenteral and enteral nutrition,
