Biomaterial Database

A diffusion tensor imaging study in essential tremor. 2011

Liu Jia, and Shen Jia-Lin, and Dong Qin, and Lu Qing, and Zhou Yan

Department of Radiology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

OBJECTIVE Essential tremor (ET) is suggested to be a neural degenerative disease. The authors investigated the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value in basal ganglia, thalamus, red nucleus, and substantia nigra in ET patients using diffusion tensor image (DTI). METHODS DTI examination was carried out in patients with ET and controls. FA and ADC values were obtained from various brain structures, including caudate, putamen+pallidum, thalamus, red nucleus, and substantia nigra. RESULTS The ADC value of the red nuclei in patients with ET was higher compared with controls (.90 vs .77; P= .000). However, no significant differences were demonstrated for FA, or ADC values of other structures. CONCLUSIONS The increased ADC value in the red nucleus indicates that there is neuronal damage or loss present, suggesting that ET may be a neurodegenerative disease.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old
D016880	Anisotropy	A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.	Anisotropies
D056324	Diffusion Tensor Imaging	The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.	Diffusion Tractography,DTI MRI,Diffusion Tensor MRI,Diffusion Tensor Magnetic Resonance Imaging,Diffusion Tensor MRIs,Imaging, Diffusion Tensor,MRI, Diffusion Tensor,Tractography, Diffusion
D020329	Essential Tremor	A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)	Benign Essential Tremor,Familial Tremor,Hereditary Essential Tremor,Benign Essential Tremors,Essential Tremor, Benign,Essential Tremors,Essential Tremors, Benign,Familial Tremors,Tremor, Benign Essential,Tremor, Essential,Tremor, Familial,Tremors, Benign Essential,Tremors, Essential,Tremors, Familial