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Long arm deletion of chromosome 7 unrelated to original karyotype in recurrent t(8;21) acute myeloblastic leukemia. 1990
M Taniwaki, and
H Nakagawa, and
S Tanaka, and
H Nishigaki, and
S Horiike, and
K Nishida, and
S Tsuda, and
S Misawa, and
J Inazawa, and
T Abe
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
We describe a chromosomal abnormality, 7q-, unrelated to the original karyotype in a patient with recurrent t(8;21) acute myeloblastic leukemia. The 7q-, del(7)(q22q34), was seen in otherwise karyotypically normal cells. Cyclophosphamide was administered for 5 months during the maintenance therapy. Our observations indicate that unrelated karyotypes, besides karyotypic evolution, may be implicated in tumor cell heterogeneity and may support the previous documentation of a possibly causal relationship between chemotherapy and development of 7q-. A larger study will be required to elucidate the biologic significance, if any, of the unrelated karyotypes.
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