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A single i.v. dose (0.1 mmol Be2+/kg) of beryllium chloride prolonged the duration of pentobarbital-induced sleep and zoxazolamine-induced paralysis, in rats. The effects are correlated with changes of the pharmacokinetic parameters and with the in vitro inhibition of both aliphatic and aromatic hydroxylation of pentobarbital and zoxazolamine. In vitro N-demethylation of meperidine and aminopyrine was partially inhibited while O-demethylation of quinidine was unaffected by liver microsomes of rats pretreated with beryllium salt. The findings give clues that beryllium chloride inhibits some forms of cytochrome P-450, especially those responsible for hydroxylation of substrates, like pentobarbital and zoxazolamine.
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
January 1995,
Xenobiotica; the fate of foreign compounds in biological systems,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
December 1970,
The Biochemical journal,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
June 1986,
Life sciences,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
June 1988,
Laboratory animal science,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
April 1978,
Experimental and molecular pathology,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
November 1980,
Biochimica et biophysica acta,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
December 1999,
Pharmacology & toxicology,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
March 1972,
Chemico-biological interactions,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
January 1974,
Environmental physiology & biochemistry,
C F Teixeira, and
W J Yasaka, and
L F Silva, and
T T Oshiro, and
S Oga
April 1994,
Toxicology,
