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To determine the mechanism by which haematopoiesis is suppressed in aplastic anaemia, the effect of the sera from 6 patients on the granulopoietic precursors (colony-forming units in culture; CFU-C) was studied in vitro. Addition of the sera from 2 patients significantly suppressed CFU-C. The suppressive effect of the sera on CFU-C was inhibited by the addition of 1.5 NU/ml of anti-gamma-IFN antibody. In another patient, anti-gamma-IFN antibody increased autologous CFU-C although the serum of the patient did not suppress CFU-C. Serum gamma-IFN levels of all patients were under 2 IU/ml. The above findings suggest that humoral factors inhibit haematopoiesis in some patients with aplastic anaemia, and that gamma-IFN plays a role as an inhibitor even at a low concentration.
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
October 1982,
British journal of haematology,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
December 2001,
British journal of haematology,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
March 1994,
Annals of internal medicine,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
May 1976,
Irish journal of medical science,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
July 1974,
British medical journal,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
December 1976,
Irish journal of medical science,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
October 1976,
Lancet (London, England),
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
January 1983,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
February 1980,
The New Zealand medical journal,
S Tohda, and
T Suzuki, and
K Nagata, and
N Nara, and
N Aoki
December 1990,
British journal of haematology,
