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To test the tumorigenic potential of aminopyrine, an antipyretic analgesic, it was administered in drinking water at levels of 0 (control), 0.04 and 0.08% to 50 male and 50 female B6C3F1 mice for 100 weeks, and the mice were subsequently maintained without aminopyrine for a further 4 weeks. The most frequent types of tumor, in both treated and control groups, were hepatocellular tumor in male mice and malignant lymphoma/lymphoid leukemia in female mice. No statistically significant differences were observed in the incidences of these tumors between treated and control groups. The incidences of several other tumors in male and female mice also showed no statistically significant differences between treated and control groups. Therefore, no tumorigenic effect of orally administered aminopyrine in B6C3F1 mice was apparent in the present study.
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
June 1985,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
June 1994,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
August 1975,
Mutation research,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
October 1988,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
March 1975,
British journal of cancer,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
September 1970,
Infection and immunity,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
January 2003,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
June 1984,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
August 1992,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Inai, and
T Kobuke, and
M Fujihara, and
S Yonehara, and
T Takemoto, and
T Tsuya, and
A Yamamoto, and
Y Tachiyama, and
K Izumi, and
S Tokuoka
May 2024,
National Toxicology Program technical report series,
