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Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue. 2010
Weidong Hu, and
Ping'an Wang, and
Chuanjun Song, and
Zhenliang Pan, and
Qiang Wang, and
Xiaohe Guo, and
Xuejun Yu, and
Zhenhua Shen, and
Shuyang Wang, and
Junbiao Chang
Department of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, PR China.
2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication.
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