The University of Minnesota Otitis Media Research Center, formed in 1978, comprises a multidisciplinary research team in the clinical fields of otolaryngology, pediatrics, audiology, and infectious disease as well as the basic science fields of histopathology, epidemiology, microbiology, immunology, biostatistics, pharmacology, physiology, and biochemistry. The team has focused on studies designed to elucidate the pathophysiology of the otitis media continuum, and considerable progress has been made in describing this continuum by using the basic science approaches available in the Center. The collaboration of basic and clinical scientists has created a synergy of goals, ideas, and methods leading to new hypotheses and progress, ultimately resulting in improved patient care methods.