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In a recent genome-wide association study of follicular lymphoma (FL), we identified novel risk alleles on chromosome 6p21.33 that appeared to be part of an extended haplotype including HLA-DRB1*0101, DQA1*0101, and DQB1*0501. To follow up on these findings, we obtained 2-4 digit HLA-DQB1 allelotypes on a subset of 265 cases of FL and 757 controls using a novel assay that applies multiplexed ligation-dependent probe amplification (MLPA). We confirmed a positive association between FL and the HLA-DQB1*05 allele group (OR = 1.70, 95% CI 1.28-2.27; adjusted p-value = 0.013) and also identified an allele group inversely associated with FL risk, HLA-DQB1*06 (OR = 0.51, 95% CI 0.38-0.69; adjusted p-value = 4.46 × 10(-5)). Although these findings require verification, the role of HLA class II proteins in B-cell survival and proliferation makes this a biologically plausible association.
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
January 2005,
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
October 2007,
Ginekologia polska,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
August 2002,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
March 2014,
Genes and immunity,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
November 2008,
Journal of dermatological science,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
May 1994,
International journal of cancer,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
November 2005,
Archives of dermatological research,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
January 2016,
Immunological investigations,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
January 2024,
HLA,
Nicholas K Akers, and
John D Curry, and
Lucia Conde, and
Paige M Bracci, and
Martyn T Smith, and
Christine F Skibola
November 1994,
International journal of cancer,
