-transparent.png){kind=logo}
Neuroendocrinological effects of L-threo-3, 4-dihydroxyphenylserine (DOPS), a putative norepinephrine precursor, on healthy volunteers. 1990
Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University.
The effect of L-threo-3, 4-dihydroxyphenylserine (DOPS) on plasma cortisol, prolactin, thyrotropin-stimulating hormone (TSH) and growth hormone concentrations was studied in nine healthy male volunteers. The drug was administered orally (300 mg or 600 mg DOPS) using a multiple crossover placebo-controlled study design. Plasma hormone concentrations were measured at 30 minute intervals for 3 hours after dosing. Plasma DOPS peak concentrations were observed between 2 and 3 hours after dosing. DOPS, however, had no effect on plasma hormone concentrations and this may be attributed to the known low brain permeability of DOPS in healthy subjects.
Related Publications
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
September 1986,
Archives internationales de pharmacodynamie et de therapie,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
April 1976,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
March 1990,
Japanese journal of pharmacology,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
January 2006,
Cardiovascular drug reviews,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
November 1994,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
January 1987,
Japanese journal of pharmacology,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
January 1988,
Life sciences,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
March 1987,
Biochemical and biophysical research communications,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
January 1985,
Journal of medicine,
J Semba, and
M Nankai, and
Y Okubo, and
M Kato, and
M Matsuura, and
R Takahashi
August 1985,
Psychiatry research,
