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Cysteine-activated hydrogen sulfide (H2S) donors. 2011

Yu Zhao, and Hua Wang, and Ming Xian
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.

H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D006862 Hydrogen Sulfide A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed) Hydrogen Sulfide (H2(Sx)),Hydrogen Sulfide (H2S2),Hydrogen Sulfide (H2S3),Sulfide, Hydrogen

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