Clinical review: Guyton--the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output. 2010

William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada. williamhenderson@shaw.ca

Arthur Guyton's concepts of the determinative role of right heart filling in cardiac output continue to be controversial. This paper reviews his seminal experiments in detail and clarifies the often confusing concepts underpinning his model. One primary criticism of Guyton's model is that the parameters describing venous return had not been measured in a functioning cardiovascular system in humans. Thus, concerns have been expressed in regard to the ability of Guyton's simplistic model, with few parameters, to model the complex human circulation. Further concerns have been raised in regard to the artificial experimental preparations that Guyton used. Recently reported measurements in humans support Guyton's theoretical and animal work.

UI MeSH Term Description Entries
D008955 Models, Cardiovascular Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment. Cardiovascular Model,Cardiovascular Models,Model, Cardiovascular
D010827 Physiology The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002302 Cardiac Output The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat). Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D003326 Coronary Circulation The circulation of blood through the CORONARY VESSELS of the HEART. Circulation, Coronary
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D049673 History, 20th Century Time period from 1901 through 2000 of the common era. 20th Century History,20th Cent. History (Medicine),20th Cent. History of Medicine,20th Cent. Medicine,Historical Events, 20th Century,History of Medicine, 20th Cent.,History, Twentieth Century,Medical History, 20th Cent.,Medicine, 20th Cent.,20th Cent. Histories (Medicine),20th Century Histories,Cent. Histories, 20th (Medicine),Cent. History, 20th (Medicine),Century Histories, 20th,Century Histories, Twentieth,Century History, 20th,Century History, Twentieth,Histories, 20th Cent. (Medicine),Histories, 20th Century,Histories, Twentieth Century,History, 20th Cent. (Medicine),Twentieth Century Histories,Twentieth Century History
D049674 History, 21st Century Time period from 2001 through 2100 of the common era. 21st Century History,21st Cent. History (Medicine),21st Cent. History of Medicine,21st Cent. Medicine,Historical Events, 21st Century,History of Medicine, 21st Cent.,History, Twenty-first Century,Medical History, 21st Cent.,Medicine, 21st Cent.,21st Cent. Histories (Medicine),21st Cent. Medicines,21st Century Histories,Cent. Histories, 21st (Medicine),Cent. History, 21st (Medicine),Cent. Medicine, 21st,Cent. Medicines, 21st,Century Histories, 21st,Century Histories, Twenty-first,Century History, 21st,Century History, Twenty-first,Histories, 21st Cent. (Medicine),Histories, 21st Century,Histories, Twenty-first Century,History, 21st Cent. (Medicine),History, Twenty first Century,Medicines, 21st Cent.,Twenty-first Century Histories,Twenty-first Century History

Related Publications

William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
March 1955, The American journal of physiology,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
March 1987, Journal of anesthesia,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
February 2023, European journal of anaesthesiology,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
July 1997, Naunyn-Schmiedeberg's archives of pharmacology,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
May 1967, The American journal of physiology,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
January 1979, The American journal of physiology,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
January 1984, American journal of obstetrics and gynecology,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
February 1993, Journal of applied physiology (Bethesda, Md. : 1985),
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
June 2011, Journal of clinical monitoring and computing,
William R Henderson, and Donald E G Griesdale, and Keith R Walley, and A William Sheel
March 1969, The American journal of physiology,
Copied contents to your clipboard!