Biomaterial Database

Novel hard-block polyurethanes with high strength and transparency for biomedical applications. 2011

Taeyi Choi, and Jadwiga Weksler, and Ajay Padsalgikar, and James Runt

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA.

Novel hard-block-only polyurethanes are prepared from 1,4-butanediol (BDO) and a pre-polymer synthesized separately from 1,3-bis (4-hydroxybutyl) tetramethyl disiloxane (BHTD) and 4,4'-diphenylmethane diisocyanate (MDI). Three (co)polymers using different proportions of these chain extenders were synthesized using reaction injection moulding, and their microstructure, mechanical properties and in vitro oxidative biostability were evaluated. These materials were found to form a single-phase system, and exhibit optical transparency, high elastic modulus and tensile strength, as well as significant in vitro oxidative biostability. By controlling the BDO/BHTD composition, the ductility can be tuned over orders of magnitude. These polyurethanes may be potentially suitable for biomedical applications, like electronic headers for defibrillators, pacemakers and neurostimulators, and orthopedic nail encapsulation.

UI	MeSH Term	Description	Entries
D011140	Polyurethanes	A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.	Polyisocyanates,Ostamer,Pellethane,Spandex,Ostamers,Pellethanes,Polyisocyanate,Polyurethane,Spandices
D002072	Butylene Glycols	4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.	Butanediols,Dihydroxybutanes,Glycols, Butylene
D001697	Biomedical and Dental Materials	Substances used in biomedicine or dentistry predominantly for their physical, as opposed to chemical, properties.
D012833	Siloxanes	Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.	Polysiloxane,Polysiloxanes,Siloxane
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures
D013718	Tensile Strength	The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)	Strength, Tensile,Strengths, Tensile,Tensile Strengths
D055119	Elastic Modulus	Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.	Young Modulus,Modulus of Elasticity,Young's Modulus,Elasticity Modulus,Modulus, Elastic,Modulus, Young,Modulus, Young's,Youngs Modulus
D055595	Mechanical Phenomena	The properties and processes of materials that affect their behavior under force.	Mechanical Concepts,Mechanical Processes,Mechanical Phenomenon,Mechanical Process,Concept, Mechanical,Concepts, Mechanical,Mechanical Concept,Phenomena, Mechanical,Phenomenon, Mechanical,Process, Mechanical,Processes, Mechanical
D058105	Polymerization	Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).	Polymerizations
D017953	Isocyanates	Organic compounds that contain the -NCO radical.	Isocyanate