-transparent.png){kind=logo}
Maturation of glycoprotein B (gB) of human cytomegalovirus (HCMV) includes a series of sequential glycosylation steps followed by proteolytic cleavage of the precursor protein. Inhibitors of glycosylation and glycoprotein processing, including tunicamycin, monensin, and bromoconduritol, were used to define further the processing pathway of HCMV gB. The results of these studies indicated that cotranslational glycosylation and intracellular transport are essential for subsequent cleavage of the precursor; early trimming in the endoplasmic reticulum is not a prerequisite but facilitates this processing event. Analysis of purified nuclei with gB-specific monoclonal antibody suggested that the mannose-rich gB-precursor intermediate(s) is (are) compartmentalized in the nuclear fraction. Immunoelectron microscopy revealed that HCMV gB was localized in the outer as well as in the inner nuclear membranes of HCMV-infected fibroblasts.
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
July 1997,
The Journal of general virology,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
January 1998,
Research in virology,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
June 2002,
Journal of virology,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
October 2015,
PLoS pathogens,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
February 2008,
Pathologie-biologie,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
May 2015,
Talanta,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
November 2015,
PLoS pathogens,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
June 1996,
Journal of medical virology,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
August 2011,
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
K Radsak, and
K H Brücher, and
W Britt, and
H Shiou, and
D Schneider, and
A Kollert
September 1996,
Journal of medical virology,
