-transparent.png){kind=logo}
Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles.
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
December 1989,
Brain research bulletin,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
March 1996,
Journal of neuroscience research,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
September 1993,
Brain research,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
December 1994,
Neuroreport,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
April 2012,
Psychopharmacology,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
February 1994,
Neuroscience,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
December 1997,
Brain research. Molecular brain research,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
November 1993,
Brain research,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
February 1994,
Brain research,
N Aronin, and
S M Sagar, and
F R Sharp, and
W J Schwartz
November 1992,
Brain research. Molecular brain research,
