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Two cases of Japanese girls with congenital cutis laxa associated with cardiovascular abnormalities are described. Case 1: A 12-year-old girl has been under our observation from the age of 6 months. Cardioangiogram revealed dilatation of the ascending aorta, meandering of the descending aorta and the coronary arteries, coiling of the carotid and innominate (brachiocephalic) arteries, and hypoplasia of the pulmonary arteries. Case 2: A 2.8/12-year-old girl died after our follow-up from the age of 3 months. The cause of death was congestive heart failure secondary to peripheral stenosis of the pulmonary arteries. In both cases, skin biopsy revealed a decreased number of elastic fibers and an increased amount of acidic mucopolysaccharides. The same histological features were observed in the pulmonary arteries and other arteries as well. Electron microscopic findings were diffuse thinning of elastic fibers and reduced elastic content. The high blood level of elastase (167.8 micrograms/l) in case 1 may cast a light on the unknown etiology of the disease.
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
October 1970,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
July 2013,
Indian journal of dermatology,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
April 1999,
Annales de dermatologie et de venereologie,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
January 2004,
Indian journal of dermatology, venereology and leprology,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
January 2010,
Annals of Saudi medicine,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
January 1989,
Dermatologica,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
January 1978,
Paediatrica Indonesiana,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
June 2003,
Indian pediatrics,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
October 1986,
Clinical genetics,
A Tsuji, and
J Yanai, and
T Miura, and
Y Shirai, and
M Osano, and
Y Hosoda, and
M Sato, and
T Asaishi, and
Y Oda, and
H Hajikano
January 1984,
Medicina cutanea ibero-latino-americana,
