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Intrauterine effect of alcohol on the development of cytomorphological structure of CNS in rats was studied by heterogeneous enzyme-linked immunosorbent assay. The level of transforming growth factor-β1 (TGF-β1) in animals during pregnancy was analyzed. Pronounced damaging effect of alcohol on brain cell in the progeny of alcoholized animals was demonstrated: loosening of nerve cells and degenerative changes in the form of pyknosis and chromatolysis in the cortex, hypothalamus, and cerebellum; subtotal decrease (sometimes complete absence) of neuroendocrine granules. The level of TGF-β1 was significantly increased in alcoholized pregnant females, which can attest to defects of the receptor apparatus of the target cells in both females and the progeny. Thus, the observed peculiarities of TGF-β1 expression are comparable to morphological changes in the brain and can be extrapolated to similar processes in humans (fetal alcohol syndrome).
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
October 2017,
American family physician,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
February 2010,
Archivos argentinos de pediatria,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
January 2006,
Annali dell'Istituto superiore di sanita,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
January 1984,
Issues in mental health nursing,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
August 2016,
Developmental medicine and child neurology,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
January 1988,
Vestnik Akademii meditsinskikh nauk SSSR,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
January 2010,
Alcohol (Fayetteville, N.Y.),
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
March 1998,
Obstetrics and gynecology clinics of North America,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
May 1992,
Biulleten' eksperimental'noi biologii i meditsiny,
V I Shilko, and
Zh L Malakhova, and
A A Bubnov
January 1981,
Neurobehavioral toxicology and teratology,
