-transparent.png){kind=logo}
After the administration of equal doses of sodium dichromate, chromium concentrations in the kidney were lower in young than in adult rats. To test the age-dependent sensitivity to the nephrotoxicity of dichromate, young and adult rats were given doses to achieve identical chromium concentrations in the kidney. At equal renal concentrations, young rats had less functional and morphological damage than adult rats. As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age.
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
January 1988,
Experimental pathology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
January 1991,
Archives of toxicology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
January 1992,
Archives of toxicology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
January 1986,
Experimental pathology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
August 1976,
Toxicology and applied pharmacology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
September 1969,
Endocrinology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
October 2009,
Chemico-biological interactions,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
April 1988,
Archives of toxicology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
August 2018,
Journal of biochemical and molecular toxicology,
D Appenroth, and
S Gambaryan, and
K H Friese, and
H Bräunlich
January 1978,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
