Biomaterial Database

Disposition kinetics, renal clearance and excretion of ampicillin after oral administration in goats. 1990

M Nawaz, and R Tabassum, and T Iqbal, and Z Perveen

Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.

Disposition kinetics, renal clearance and urinary excretion of ampicillin were determined after oral administration of 10 mg/kg in 8 goats. Peak plasma concentration 1.86 +/- 0.14 mumol/l was attained at 117 +/- 11 min after oral administration. Half-time of absorption was 28.7 +/- 5.8 minutes and that of elimination was 135 +/- 15 minutes. Total area under plasma concentration versus time curve was 9.16 +/- 0.97 mumol.h/l. Total body clearance of ampicillin was 52.1 +/- 4.2 and renal clearance was 0.07 +/- 0.008 ml/min.kg. The renal handling of ampicillin involved glomerular filtration and back diffusion.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005260	Female		Females
D006041	Goats	Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.	Capra,Capras,Goat
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000667	Ampicillin	Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.	Penicillin, Aminobenzyl,Amcill,Aminobenzylpenicillin,Ampicillin Sodium,Ampicillin Trihydrate,Antibiotic KS-R1,Omnipen,Pentrexyl,Polycillin,Ukapen,Aminobenzyl Penicillin,Antibiotic KS R1,KS-R1, Antibiotic,Sodium, Ampicillin,Trihydrate, Ampicillin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia